Locoregional recurrence following nipple-sparing mastectomy with immediate breast reconstruction: Patterns and prognostic significance

IntroductionThere are limited available data on the prognostic implications of locoregional recurrence (LRR) after nipple-sparing mastectomy (NSM) and immediate reconstruction. In this study, we investigated patterns prognosis associated with LRR following treatment approach for breast cancer.MethodsA total 1696 patients primary cancer who underwent NSM reconstruction from March 2003 to December 2016 were retrospectively analyzed. Post-recurrence disease-free survival (DFS) distant metastasis-free (DMFS) rates calculated using Kaplan-Meier method compared log-rank test. Univariate multivariate analyses Cox proportional hazards model performed evaluate factors DFS DMFS.ResultsAfter a median follow-up period 84 months, identified 172 (10.1%) an as first event. The 5-year post-recurrence nipple-areola complex (NCR), skin or subcutaneous recurrence/chest wall (SCR/CWR), regional (RR) groups 89.1%, 73%, 59.4%, respectively (P = 0.009), DMFS NCR, SCR/CWR, RR 96%, 82.8%, 59.7%, < 0.001). analysis, time ?2 years 0.016) site 0.022) significantly DFS.ConclusionsNCR is more likely be detected non-invasive favorable overall outcomes than other types. interval its onset seem outcomes.